From patients to discoveries

CRYOSTEM, a national cohort dedicated to the complications of Hematopoietic Stem Cell Transplantation (HSCT)

Biological resources

The patient-biobank duo:
the two pillars of novel precision medicine

Calls for project

CRYOSTEM supports international projects aimed to to better prevent, diagnose and treat the complications of HSCT


A collection unique in Europe

Launched within the framework of Investments for the Future by the National Research Agency (ANR), at the heart of the French Government’s Plan Cancer and supported by the National Cancer Institute (INCa), the CRYOSTEM’s project was initiated in 2011 under the auspices of the Francophone Society of Marrow Transplantations and Cellular Therapy (SFGM-TC) to accelerate research in the area of complications of Hematopoietic Stem Cell Transplantation (HSCT), previously called bone marrow transplantation.



Today the CRYOSTEM community offers academic and industrial research teams, a collection of almost 200 000 samples to address life-threatening complications of HSCT.

Claire Fontenille
Project Manager CRYOSTEM



CRYOSTEM is a wonderful opportunity for researchers to better understand the biological mechanisms, to improve the prevention and the management of the complications of HSCT.

Dr. Claire Galambrun
Department of Pediatric Hematology,
The Timone Hospital

CRYOSTEM could play a significant role to predict the transplant toxicity.

Dr. Boris Calmels
Department of Hematology and Cell Therapy
Institut Paoli-Calmettes,
Founding Member of CRYOSTEM

In 2016 CRYOSTEM obtained the authorization to extend its collection to all the complications of HSCT.

Dr. Emilie Robert
Project Manager CRYOSTEM

What interests us it is being able to discriminate early before transplantation between patients who are going to benefit from the treatment.

Pr. Régis Peffault de Latour
Department of Hematology,
The Saint Louis Hospital,
Founding Member of CRYOSTEM

An informed patient is a better armed patient : at U2T, we use games to increase patients awareness of the HSCT complications.

Laurence Caymaris
Nurse Supervisor
Department of Onco-Hematology,
Institut Paoli-Calmettes


of transplanted patients in France

  • 5 610 Recipients
  • 2 328 Donors
  • 16 622 Sampling
  • 47 878 Samples (194 637 aliquots)

News & events

Pas d'Événement



CD24(hi)CD27⁺ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease. Blood. 2015 Mar 12;125(11):1830-9. doi: 10.1182/blood-2014-09-599159.

SOCIÉ G. ET AL., 2014

Current issues in chronic graft-versus-host disease. Blood. 2014 Jul 17;124(3):374-84. doi:10.1182/blood-2014-01-514752.

DONG S. ET AL., 2013

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease. Blood. 2013 Sep 5;122(10):1802-12. doi: 10.1182/blood-2013-02-482539.


Fecal calprotectin and alpha-1 antitrypsin predict severity and response to corticosteroids in gastrointestinal graft-versus-host disease. Blood. 2012 Jun 14;119(24):5909-17. doi: 10.1182/blood-2011-12-397968.


More information about CRYOSTEM