From patients to discoveries
CRYOSTEM, a national cohort dedicated to the complications of Hematopoietic Stem Cell Transplantation (HSCT)
CRYOSTEM biospecimen collection
Throughout the year, CRYOSTEM encourages researchers to apply for samples access
CRYOSTEM supports fundamental, translational and clinical research projects in the field of HSCT complications
CRYOSTEM develops tailor-made biobanking network solutions for innovative projects and medical research
A collection unique in Europe
Launched within the framework of Investments for the Future by the National Research Agency (ANR), at the heart of the French Government’s Plan Cancer and supported by the National Cancer Institute (INCa), the CRYOSTEM’s project was initiated in 2011 under the auspices of the Francophone Society of Marrow Transplantations and Cellular Therapy (SFGM-TC) to accelerate research in the area of complications of Hematopoietic Stem Cell Transplantation (HSCT), previously called bone marrow transplantation. Today, CRYOSTEM brings together all French transplant units, 28 Biological Resource Centers (BRC) as well as more than 400 French research and healthcare players in the field of severe blood diseases.More
CRYOSTEM partnering centers
(transplant units and biological resource centers)
Today the CRYOSTEM community offers academic and industrial research teams, a collection of almost 200 000 samples to address life-threatening complications of HSCT.
CRYOSTEM regulatory and operational manager
CRYOSTEM is a wonderful opportunity for researchers to better understand the biological mechanisms, to improve the prevention and the management of the complications of HSCT.
Dr. Claire Galambrun
Department of Pediatric Hematology,
The Timone Hospital
CRYOSTEM could play a significant role to predict the transplant toxicity.
Dr. Boris Calmels
Department of Hematology and Cell Therapy
Founding Member of CRYOSTEM
Throughout the year, CRYOSTEM encourages researchers to apply to gain access to the collection.
Dr. Emilie Robert
CRYOSTEM strategy and development manager
What interests us it is being able to discriminate early before transplantation between patients who are going to benefit from the treatment.
Pr. Régis Peffault de Latour
Department of Hematology,
The Saint Louis Hospital,
Founding Member of CRYOSTEM
An informed patient is a better armed patient : at U2T, we use games to increase patients awareness of the HSCT complications.
Department of Onco-Hematology,
of transplanted patients in France
- 5 985 Recipients
- 2 437 Donors
- 17 990 Blood samples
- 51 357 Samples (199 991 aliquots)
- 8 256 Provided samples
News & events
Opening of Registration for CRYOSTEM Scientific Day 2023Registrations are now opened for CRYOSTEM 6th edition scientfic day…
The CeVi CAR-T collection has recruited its 200th patient!The Carnot Institute CALYM and CRYOSTEM have been collaborating since…
A new recruit in the CRYOSTEM network coordinationSince October 24, 2022, we are delighted to welcome our…
VALLET N. ET AL., 2022
Azithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation. Blood
LUPO J. ET AL., 2022
High Predictive Value of the Soluble ZEBRA Antigen (Epstein-Barr Virus Trans-Activator Zta) in Transplant Patients with PTLD. Pathogens
DUBOUCHET L. ET AL., 2022
Operational tolerance after hematopoietic stem cell transplantation is characterized by distinct transcriptional, phenotypic, and metabolic signatures. Science Translational Medicine.
TOURRET M. ET AL., 2021
Human MAIT cells are devoid of alloreactive potential: prompting their use as universal cells for adoptive immune therapy. Journal for ImmunoTherapy of Cancer.
PIPEROGLOU C, LARID G, VALLENTIN B, ET AL., 2021
Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation. J Leukoc Biol.
LATIS E. ET AL., 2020
Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD. Blood Advances.
ROBERT E. ET AL, 2020
“CRYOSTEM Biobank: A National Prospective, Standardized Collection to Better Characterize Allogeneic Hematopoietic Stem Cell Transplantation Complications”. Open Journal of Bioresources.
MICHONNEAU D. ET AL., 2019
Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites. Nature Communications.
DE MASSON A. ET AL., 2015
CD24(hi)CD27⁺ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease. Blood.