From patients to discoveries

CRYOSTEM, a national cohort dedicated to the complications of Hematopoietic Stem Cell Transplantation (HSCT)


Launched within the framework of Investments for the Future by the National Research Agency (ANR), at the heart of the French Government’s Plan Cancer and supported by the National Cancer Institute (INCa), the CRYOSTEM’s project was initiated in 2011 under the auspices of the Francophone Society of Marrow Transplantations and Cellular Therapy (SFGM-TC) to accelerate research in the area of complications of Hematopoietic Stem Cell Transplantation (HSCT), previously called bone marrow transplantation.

Today, this national collective has made it possible to constitute a collection rich in the biological resources of 82% of transplanted patients in France, i.e. nearly 200,000 biological samples taken pre- and post-transplant, from more than 5,900 patients and 2,400 donors (data as of December 31, 2021 – date of the end of collection).

From this resource with very high biological and clinical value added, scientists around the world attempt to extract new knowledge allowing them to better prevent, diagnose and treat the complications of HSCT.

All the research projects supported by CRYOSTEM meet rigorous selection criteria, defined by a scientific committee that brings together leading world experts in immunology, oncology and infectious diseases. This scientific excellence is widely recognized by the patients’ associations specialized in the field of blood-related diseases that have supported CRYOSTEM since its inception.

This unique collection in Europe brings together biological samples and associated data from :

  • recipients, and, for some of them, their donors, at pre-transplant sampling periods ;
  • recipients at post-transplant systematic sampling periods (100 days, one and two years post-transplant), and at the occurence of Graft-versus-Host Disease – acute and chronic -and in the aftermath of the treatments implemented.
le collectif cryostem